The drug has a pronounced hypolipidemic action. The composition of tablets includes the active ingredient simvastatin, which is converted into the active compounds in the hydrolysis process. Metabolite of simvastatin inhibits the enzyme HMG-COA reductase. This enzyme participates in the biosynthesis of cholesterol.
As a consequence, the influence of Zocor decreases the level of cholesterol in the body and also cholesterol, which is binded with lipoproteins of low and very low density. It also reduces the content of cholesterol in plasma of triglycerides.
At the same time simvastatin increases the level of cholesterol, which is binded with lipoproteins of high-density.
The effectiveness of the drug is noted in different types of hyperlipidemia, particularly heterozygous, family and non-family ones. Also the drug is effective in mixed types of hyperlipidemia in the case if diet is not sufficient to normalize lipid content in the plasma.
The amount of lipids in plasma is reduced in 14 days after the start of treatment. Thus the highest values occur in the period from 4 to 6 weeks of treatment. Such a result is saved during the further reception of the drug.
When the treatment is completed gradually, the level of total cholesterol in plasma returns to baseline which was recorded before the reception of the drug.
If you want to buy Zocor, you should fill out the order form or contact us at the telephone number listed on the website. The operator will answer all your questions. Our company can guarantee that we offer the drug at the lower price than at the pharmacy and it always has high quality, so all deliveries will be executed only from manufacturers that have been already established around the world.
Pharmacokinetics and pharmacodynamics
The highest concentration of blood metabolites of simvastatin is observed in 1.3-2.4 hours after taking one dose of the drug. The body absorbs about 85% of simvastatin taken orally.
After the reception the highest concentration of active substance is noticed in the liver compared to other tissues,.
Simvastatin is metabolized in the process of the first pass through the bloodstream of the liver, then the drug and its metabolites are excreted in the bile.
Eating immediately after taking the medication will not interfere with the pharmacokinetics of the drug. Simvastatin does not accumulate in the body tissues in case of long-term treatment.
Indications for use
Zocor is taken by people who belong to the group with high risk of coronary heart disease independently of blood lipids. The risk group includes people with the following comorbid conditions:
cerebrovascular disease, including stroke (history);
diabetes (the drug can prevent the manifestation of peripheral vascular complications and reduce the need for revascularization and amputation of the lower limbs);
pathology of peripheral blood flow.
The medicine is used in the treatment of people diagnosed with coronary artery disease and patients with hypercholesterolemia. In this case Zocor can prevent the manifestation of atherosclerotic lesions of blood vessels in the heart, the development of other complications.
Zocor is also be prescribed to adult patients in the following cases:
high total cholesterol, apolipoprotein b and cholesterol which is binded with lipoprotein of low density, in combination with diet;
low level of cholesterol of lipoproteins of high density, which is associated with primary hypercholesterolemia against the background of dieting;
homozygous familial form of hypercholesterolemia in parallel with other methods of treatment and diet.
You can buy Zocor in any quantity on our website.
Absolute contraindications to the use of Zocor are:
impaired absorption and metabolism of lactose;
acute liver disease, a significant and steady increase in transaminases of unknown origin;
pregnancy and breastfeeding;
the age of 10.
Relative contraindications to the use of Zocor are:
the decrease in kidney function;
the decrease in the function of the liver;
diabetes, lasting many years;
In such cases, the medication is prescribed with caution.