Vytorin represents a combination of two active components, Ezetimibe and Simvastatin. This drug is mainly used for the treatment of dyslipidemia (elevation of plasma cholesterol, triglycerides). Because of the unhealthy diet and lifestyle, more and more people suffer from this disease.
Manufactured by Merck & Co/Schering-Plough Pharmaceuticals, this drugs acts in two different ways. While Simvastatin blocks the release of HMG-CoA, an enzyme helping the body to produce cholesterol, Ezetimibe supplies a statin that links to the brush border membrane of the small intestine, preventing the absorption of cholesterol into the organism. Together with a balanced diet, this drug can reduce the level of cholesterol and triglycerides in blood, allowing the patients to prevent certain health problems, such as liver dysfunction, hypertension and heart attack.
Because of its double action, Vytorin can be used for the treatment of specific conditions, like a hereditary high blood cholesterol disorder, heterozygous high cholesterol, and combined high blood cholesterol and triglyceride levels.
Before getting a prescription for this drug, patients must be aware of the possible interactions between its components and other drugs. While the active components of this drug are Simvastatin and Ezetimibe, some of its inactive components are: citric acid monohydrate USP, lactose monohydrate NF, hypromellose USP, magnesium stearate NF and microcrystalline cellulose NF.
If this drug must be taken in combination with immunosuppressant, birth control pills, hepatitis C, AIDS, depression, antifungals or pain killers, the doctors may change the dose or the interval between them intakes. Moreover, particular drugs, including telaprevir and boceprevir, may prevent the metabolic pathway of Simvastatin, enhancing the risk of myopathy. As alcohol, cranberry or grapefruit juice may affect the performance of Simvastatin and Ezetimibe, patients must avoid mixing these drugs with Vytorin.
As the combination of Simvastatin and Ezetimibe is prescribed on the basis of the certain blood test results, you must not buy Vytorin before visiting your doctor. Moreover, you should never exceed the dose or take it longer than necessary, as an overdose of Simvastatin and Ezetimibe may enhance the risk and severity of certain adverse reactions. As Simvastatin and Ezetimibe may affect fetus, and even lead to the congenital defects, pregnant women must not use this medication. A mixture of Simvastatin and Ezetimibe is also contraindicated for the patients with liver disorders, and lactating women.
People who want to use Vytorin for the treatment of a cholesterol-related disease should know that they may experience certain adverse effects, including depression, upper respiratory tract infection, head pain, weakness, angioedema, stomachache, myalgia, rhabdomyolysis and myopathy. People who have allergy to Simvastatin and Ezetimibe, or suffer from kidney dysfunction, diabetes or thyroid problems, should also refuse from any Simvastatin and Ezetimibe combination.
On rare occasions, this drug may cause a condition that breaks down the skeletal muscle tissue, leading to the renal failure. Usually, this condition happens in Chinese descents, elderly people, or in people with kidney diseases or underactive thyroid gland.