Tramadol is a pain medication that belongs to opioids. It is usually used for the treatment of pain. The medicine is especially powerful in the treatment of moderate and severe pain. This is a fast-reacting opioid, therefore Tramadol is usually used by people suffering from severe pain. The main active substance of the drug is Tramadol hydrochloride. The drug was released at the end of the 1970s in Germany, and twenty years later it became available in other countries. Tramadol is available in the immediate release and extended release form.
Tramadol provides pain relief 1 hour after the intake. Its action lasts for up to 6 hours. The drug is marketed as Tramadol and is known under different other names all over the world.
The action of Tramadol
Tramadol relieves pain by modulating the pain feelings in the brain. The purpose of Tramadol is to deceive the brain as regards how it perceives the pain signals. Actually, the working mechanism of Tramadol is very different from other non-prescription pain medications, as it affects the inflammatory mediators.
Tramadol stops the reuptake of neurotransmitters, such as norepinephrine and serotonin. This process leads to the activation of opioid receptors in the CNS. As a result, pain transmission occurring in the spinal cord is completely restricted. As soon as the activation of micro-opioid receptors happen in the CNS, patients feel significant relief.
Can Tramadol be used by everyone?
Tramadol can be used by people of different body type and age. As this medicine can cause addiction, you should use it very carefully. Inform the doctors about any drugs you’re taking before starting the treatment with Tramadol. However, the drug can be used by patients with serious health complications. You can experience strong pain relief from Tramadol, if you take it strictly according to the doctor’s prescription. Moreover, Tramadol is very effective for the treatment of neuropathic pain.
Tramadol must be used every day for the treatment of moderate to severe pain.
For the treatment of moderate pain, you should take the immediate release drug in the dosage of 50-100mg. It must be taken with an interval of 4-6 hours. The maximum daily dosage is 400 mg.
For the treatment of chronic pain, you should use the extended-release tablets. The drug must be taken orally in the dosage of 100 mg. Never take more than 300 mg a drug a day.
Follow all the doctor’s precautions and be cautious during the treatment.
Even if you use Tramadol in the proper dosage, there is a risk of seizures when the drug is taken constantly for a long time.
The risk of seizure risks is increased in patients taking antipsychotics and MAO inhibitors.
The anesthetic can cause serious anaphylactoid reactions.
This drug can cause addiction.
Tramadol must not be combined with any psychoactive substances.
Opioid-dependent patients must refrain from taking Tramadol.
Never exceed the dosage of Tramadol to avoid undesirable effects.
Tramadol can adversely affect all areas of the body. Adverse effects develop in the digestive system, respiratory organs and central nervous system. Moreover, this drug can cause psychiatric disorders. The medicines can cause severe digestive side effects and general health disorders. The drug overdose can also lead to the severe adverse effects.
Over-the-counter Tramadol is a fake, as it’s very difficult to get the drug without the doctor’s prescription. Due to its opioid properties and high risk of addiction, this drug is not available without the valid prescription. Therefore, you should avoid e-pharmacy offering Tramadol pills without prescription. However, in case of emergency, you can get Tramadol over-the-counter from the safe e-pharmacy.