Serevent is a bronchodilating drug containing salmeterol, a selective agonist of type 2 beta-adrenoreceptors, which has a prolonged effect and does not affect CCC at therapeutic doses. The drug Serevent promotes the development of prolonged bronchodilation in persons with reversible airway obstruction, the effect of the drug lasts up to 12 hours. The constant use of salmeterol contributes to a steady improvement in lung function, a decrease in the severity of obstructive syndrome and night bronchoconstriction in patients with bronchial asthma. You can buy Serevent on our website.
On the background of regular use of aerosol Serevent in most patients with asthma, the need for additional application of bronchodilators disappears; however, given that the drug Serevent is not a means for relieving acute episodes of bronchospasm, such patients should always carry short-acting dilators with bronchus.
In experiments in vitro, salmeterol, in addition to direct bronchodilator action, led to a decrease in the release of leukotrienes, histamine and prostaglandins from mast cells, which led to the inhibition of the early and late stages of the allergic reaction. After a single use of the Serevent aerosol, there was a decrease in the hyper-reactivity of the bronchi, which indicates the anti-inflammatory activity of salmeterol. The mechanism of direct and mediated bronchodilator action, as well as the inhibition of the reaction of the allergic type and the anti-inflammatory effect of salmeterol, differs from that of corticosteroids, so that the previously prescribed corticosteroids for oral or inhalational administration can’t be canceled against the background of the appointment of the drug.
Inhalation application of 50 mkg of the drug Serevent twice a day resulted in the peak serum concentration of the active substance not exceeding 200 pg / ml. Serevent concentration of active substance is insignificant, when using therapeutic doses of systemic action of salmeterol is not expected. The effectiveness of the drug is not dependent on the serum concentration of salmeterol, which is associated with the implementation of the drug in the tissues of the lungs.
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Indications for use.
Serevent is used for regular and prolonged treatment of patients who have reversible airway obstruction associated with bronchial asthma, including in the presence of nocturnal seizures, as well as bronchoconstriction associated with physical exertion.
Serevent can be given to patients with chronic obstructive pulmonary disease.
The drug Serevent can be used in the treatment of patients with chronic forms of bronchitis, in the presence of severe obstruction.
Mode of application.
The drug Serevent is intended only for inhalation use. Aerosol should be used regularly, the drug is ineffective for arresting acute bronchospasm.
The dose of the drug Serevent, the scheme of therapy, as well as additional treatment is prescribed by a specialist. During treatment of patients with bronchial asthma, it is necessary to regularly monitor the general condition of patients, as well as the function of the lungs.
Adult patients with bronchial asthma and chronic lung diseases accompanied by obstructive syndrome are usually prescribed 2 inhalations of Serevent twice a day. Patients with severe airway obstruction, and if the above doses are ineffective, the amount of salmeterol can be increased to 4 inhalations twice a day. Self-correction of the dose of the drug, as well as cessation of treatment or changing the dose of concomitant therapy is unacceptable.
Patients older than 4 years are usually prescribed 2 inhalations of Serevent twice a day.
Patients under 4 years of age should not be prescribed a drug Serevent (due to the lack of clinical trials of salmeterol in this age group of patients).
Older patients, as well as those with kidney failure, do not need a dose adjustment for salmeterol.
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Use of aerosol.
The specialist should show the patient the technique of using the Serevent aerosol and also check the correctness of use. If the aerosol application is not used correctly, the amount of active substance entering the lungs decreases, which may lead to a decrease in the effectiveness of bronchodilating action. Young children with inhalation may require the help of adults.
It is necessary to clean the plastic case of the Serevent aerosol regularly, at least once a week, wiping it with a dry napkin. Do not remove the cylinder from the plastic housing, and place the product in water.
Serevent is not prescribed for patients with intolerance to salmeterol or excipients that make up the aerosol.
Care must be taken when recommending Serevent aerosol for patients suffering from thyrotoxicosis.