Indications for use
Persantine is used to treat such conditions and diseases as:
dyscirculatory encephalopathy (used for treatment);
the disruption of the micro-circulation (used for treatment only as a subsidiary product);
prevention of CHD;
prevention of thromboembolism that may occur in the postoperative period of time of the prosthetics of heart valve;
prevention and treatment of circulatory disorders of the brain of the ischemic type.
In addition, this tool is also used to treat arterial and venous thrombosis, and thrombus formation, acute respiratory viral infections and flu, placental insufficiency, malnutrition of the fetus as well as pre-eclampsia, which occurs in the the complicated form of pregnancy.
The use of the drug
The daily dosage of the drug for adults is between 70 and 225 mg which should be divided into 3-6 times.
If the patient’s condition improves, the dosage should be reduced to 25-50 mg. The maximum dosage is 600 mg and is used in severe course of the disease.
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In case of concurrent combination with anticoagulants or acetylsalicylic acid, it is necessary to prescribe Persantine at a dosage of 75 mg. The number of doses is from 3 to 6 times a day.
Pills must be taken on an empty stomach. The pills should be washed down with plenty of water.
The required dosage and duration of treatment is selected individually in each case, based on the severity of the disease. Persantine should be prescribed for a long period of time.
Release form and composition.
Persantine is available in tablets, coated tablets and solution, intended for intravenous injections.
Pills are of green-yellow and yellow color
Each pill contains 25, 50, 75, and 100 mg of dipyridamole.
Usually, drops are placed in special glass jars. The number of tablets in one pack is 100 pieces.
Interaction with other drugs
Derivatives of Persantine (including tea and coffee) can reduce the effectiveness of the vasodilator Dipyridamole in several times.
If the drug is prescribed simultaneously with cholinesterase inhibitors, it can cause a decrease in anticholinergic properties.
The simultaneous use of cephalosporin antibiotics, for example, Cefamandole, Cefoperazone, Cefotetan can increase anti-platelet effects.
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The drug leads to the formation of the negative phenomena in rare cases, and even if it happens, the effect will be mild. Such manifestations include:
Tachycardia, rapid heartbeat, sudden drop in blood pressure, bradycardia, steal syndrome;
Thrombocytopenia, increased bleeding, change of platelets;
Vomiting/nausea, diarrhea, abdominal pain. In case of prolonged medication these states disappear on their own.
General weakness, arthritis, tinnitus, rhinitis, dizziness, headache, myalgia, flushing, urticaria, rash.
Overdose may lead to such symptoms as angina, general weakness, a sharp decrease in blood pressure, dizziness.
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You should wash out the stomach and take activated charcoal. If angina persists, then you should take nitroglycerin sub-lingually.
Persantine is not recommended in case of such conditions as:
Severe form of hypertension.
The acute form of myocardial infarction.
Sub-aortic stenosis of aortic, diathesis.
Collapse, liver failure.
The chronic form of kidney failure.
Allergic to the items that are included in the composition.
Any chronic lung disease.