Description of the pharmacological action of Nolvadex.
Competitively binds to estrogen receptors in target organs, like estrogens, is translocated together with the receptor into the nucleus of the tumor cell and thus blocks the action of estrogens.
Pharmacodynamics of Nolvadex.
Well absorbed from the digestive tract, Tmax – 4-7 h, time to reach Css – 3-4 weeks. Binding to plasma proteins – 99%. Metabolized in the hepatic by hydroxylation and demethylation. Excretion is biphasic with initial T1 / 2 – 7-14 h and subsequent slow terminal T1 / 2 – 7 days. It is excreted mainly through the intestine, mainly in the form of metabolites, a small amount – by the kidneys. You can buy Nolvadex on our website.
Use of Nolvadex during pregnancy
It is contraindicated in pregnancy (before treatment, pregnancy should be excluded).
For the duration of treatment, breastfeeding should be discontinued (it is not known whether tamoxifen penetrates breast milk).
Contraindications to the use of Nolvadex.
Hypersensitivity, pregnancy, breast-feeding.
Side effects of Nolvadex.
From the nervous system and sensory organs: headache, dizziness, fatigue, depression, confusion, visual impairment, corneal changes, cataracts and retinopathy.
From the cardiovascular system and blood (hematopoiesis, hemostasis): thrombophlebitis, thromboembolism, transient leukopenia, thrombocytopenia.
On the part of the gastrointestinal tract: abdominal pain, nausea, vomiting, loss of appetite, constipation, increased level of hepatic enzymes, severe violations of the hepatic (cholestasis, hepatitis).
On the part of the genitourinary system: bleeding or vaginal discharge, amenorrhea or irregular menstruation in men before the menopause, the occurrence of reversible cystic ovarian tumor, fluid retention, itching in the genital area. Having bought from us Nolvadex you will receive the original drug with delivery to any city.
Allergic reactions: skin rash.
Other: alopecia, pain in the area of the lesion and / or in the bones, increase in the size of the soft-tissue formations (accompanied by pronounced erythema of the affected areas and adjacent areas), hypercalcemia, paroxysmal sensation of fever, fever; With prolonged use – cases of changes in the endometrium, including hyperplasia, polyps, intrauterine fibroids and in isolated cases – endometrial cancer.
Dosing and administration of Nolvadex.
Inside, with breast cancer – 20-40 mg / day (for 1 or 2 reception).
Interactions of Nolvadex with other drugs.
When combined with cyto statics, the risk of thrombus formation increases. Estrogens can reduce the therapeutic effect of tamoxifen. Can be used in combination with progestins. Potentiates the effect of anticoagulants of indirect action.
Precautions for taking Nolvadex.
Before the treatment, women should undergo a thorough gynecological examination. Tamoxifen causes ovulation, which increases the risk of pregnancy, so women of reproductive age need to use reliable contraceptive methods (non-hormonal) during treatment and for 3 months after the end of treatment.
The drug should be discontinued when bloody discharge from the vagina or vaginal bleeding occurs, signs of thrombosis of the veins of the lower extremities (pain in the legs or their swelling), thromboembolism of the branches of the pulmonary artery (dyspnea).
In the process of treatment, it is necessary to control blood coagulation indicators, blood patterns (leukocytes, platelets), hepatic function indices. Before the beginning and periodically during treatment, an opthalmologic examination is recommended.
By purchasing Nolvadex on our website, you can order the drug in any quantity.
In patients with bone metastases, the concentration of calcium in serum should be determined periodically during the initial treatment period (in the case of severe hypercalcemia, tamoxifen should be temporarily discontinued). In patients with hyperlipidemia during treatment, it is necessary to control the concentration of cholesterol and TG in serum.
It is not effective in the treatment of patients with metastases (especially in the hepatic).