The composition and form of release of the drug
Nexium is available in tablet form of pink color, covered with a protective film cover of oblong form and bulges on both sides. Tablets are packed in blisters of 7 pieces for 1, 2 or 4 blisters in a carton box which contains a user instruction with a detailed description.
Each tablet contains 20 mg of active component of Esomeprazole; also the drug includes additional substances.
Pharmacological action of the drug
The drug has an effect on the process of producing the hydrochloric acid in the stomach, protects the mucous membranes of the digestive channel from the negative impact of gastric juice.
Indications for use
Treatment and conduction of therapy of reflux esophagitis;
Treatment of peptic ulcer and prevention of recurrence of peptic ulcers;
Treatment of peptic ulcer caused by the bacterium Helicobacter pylori;
Treatment of erosive lesions of the mucous membrane of the alimentary canal, arising in a background of a long reception of steroidal anti-inflammatory substances;
Prevention of peptic ulcer and erosive gastritis of patients at risk
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Before starting therapy, patients should carefully read the accompanying user instruction. Tablets are contraindicated in the following cases:
Hereditary fructose intolerance;
Children up to 12 years of age due to the lack of clinical experience;
Individual intolerance to the drug components;
Renal failure of severe form of the flow
Method of application and dosage
Tablets are taken orally with water. It is not recommended to crush or chew the pill. The daily dose depends on the diagnosis and individual characteristics of the organism. According to the instructions, it is prescribed 2 tablets 1 time per day for the treatment of reflux esophagitis and prevention of relapse of the disease. Duration of therapy is 1 month. If the therapeutic effect is weak or the symptoms of the disease are retained, you can take the pills again with the permission of the doctor. Supportive therapy is 1 tablet 1 time per day.
Patients, who take pills of steroidal and anti-inflammatory group for a long time, should take the drug to prevent the development of peptic ulcer disease; the daily dose of the preparation is determined individually.
The use of the drug by pregnant women and nursing mothers
Nexium should not be used by pregnant women as clinical experience of the use of this medication is insufficient. In case of drug therapy, you should assess the potential risks to the fetus and benefit to the mother. Tests on animals showed no toxic action of the drug on fetal development.
It is not known whether the main active ingredient of the drug penetrates into the breast milk and how it can affect infants, so Nexium shouldn’t be used by nursing mothers. If necessary, lactation should be stopped during the drug treatment.
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In the background of the use of the drug, patients may have the following adverse reactions:
From the skin – the development of dermatitis, itchy skin, rash, allopathy, photo sensitization;
From the musculoskeletal system – muscle pain, pain in the joints, muscle weakness;
From the nervous system – headaches, dizziness, disturbance of sensation in extremities, drowsiness;
Organs of the alimentary canal – stomach pain, constipation or diarrhea, abdominal distension, stomatitis, enterocolitis development;
From the blood – reducing the number of leukocytes in the blood, thrombocytopenia, agranulocytes;
Allergic reactions – increased hypersensitivity, the development of angioedema, anaphylactic shock;
The respiratory system – the bronchial spasm;
Blurred vision, double vision, blurred vision.
From metabolism – reduced levels of sodium, magnesium and calcium in the blood.
In case of ingestion of a large number of pills, patients can notice signs of overdose, which are general weakness, disorders of the gastro-intestinal tract.
Patients can carry out the symptomatic treatment in case of the development of signs of overdose.
There is no antidote to the drug; dialysis is ineffective in this case.
Interaction with other drugs
Nexium can not be taken simultaneously with other blockers of the proton pump because pH of the hydrochloric acid changes and it increases the risk of side effects.
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It is also not recommended to use this medicine and antacids or chelators simultaneously. This drug interaction will suppress the therapeutic effect of each other.