Pharmacological effects of Hyzaar.
Hyzaar – tablets with a combined composition that provides optimal pharmacological action. The main effect of drug is anti hypertensive. Losartan minimizes the risk of developing gout from hydrochlorothiazide. Anti hypertensive effect of losartan is potentiated by diuretic, which is a part of the tablets. Hydrochlorothiazide enhances the activity of plasmatic renin molecules, potentiates the production of aldosterone molecules, increases the level of angiotensin II, decreases plasma potassium levels. Hyzaar has a blocking effect on the effects of angiotensin. You may buy Hyzaar on our website.
Angiotensin II – vasoconstrictor agent, which is one of the main links of pathogenesis of arterial hypertension. Hyzaar greatly reduces the loss of potassium ions, which triggers a diuretic by suppressing the action of aldosterone. Hyzaar has uricosuric effect of moderate intensity of transient nature.
Indications for use
The drug is prescribed in case of:
arterial hypertension (in the presence of indications for therapy with a combination of therapeutic agents);
preventive supplementation for reducing mortality and reducing risks associated with abnormalities of the heart and blood vessels (angiography, hypertrophic changes of the left ventricle).
The way to use Hyzaar
Meals do not affect the pharmacokinetics of this drug, so pills can be taken before or after and during the meal. Standard dosing for hypertension is 1 tablet/day. Buying Hyzaar on our site, you will be confident in the quality of the drug. A tablet is not broken and used at time. If you notice the absence of adequate therapeutic effect of the drug within 2-4 weeks, you should start taking the drug Hyzaar Forte or begin to take 2 tabl. of the drug per day. The initial dosage may be standard for geriatric patients.
You should take one tablet a day for the prevention of risks associated with myocardial-vascular pathologies, to reduce mortality in hypertension and hypertrophic changes of the myocardium. The dosage may be doubled, if necessary. You should increase the dosage of losartan to 100 mg/day, but it is not necessary to increase the dosage of hydrochlorothiazide.
It is impossible to prescribe the pills to pregnant women. The drug may cause fetal death. When the pregnancy is established, the drug is canceled and the woman is prescribed safe analogues of the drug. Losartan drugs have teratogenic effects, may cause death in newborns (established in animal experiments). The risk of teratogenicity is increased when receiving a therapeutic drug in 2-3 trimesters of pregnancy. The drug can also cause fetal jaundice, cause of obstructive jaundice at neonatal patients. The drug provokes thrombocytopenia to women during pregnancy.
Side effects of Hyzaar
There were no adverse reactions while taking the drug with losartan and hydrochlorothiazide. The frequency of adverse symptoms during the reception of the pills matches the frequency of undesirable effects seen when taking a placebo.
There are no clear data on symptoms of overdose of losartan. It may develop hypotension, tachycardias attack, slowing of the heart rate. The treating specialist must appoint a maintenance therapy drug for the relief of developed symptoms. The metabolites of Hyzaar aren’t excreted in the application of hemodialysis. The drug is immediately canceled in case of overdose by stimulating vomiting, correcting electrolyte disturbances. Therapy of hepatic coma and hypotension is carried out using standard methods.