Short description of Endep.
Endep is an anticonvulsant. It is effective for all types of epilepsy. Improves mood, reduces anxiety and fear. It is used to treat manic-depressive syndrome of seizures that occur at high temperature and ticks in children. It is characterized by good tolerability, easy and reversible side effects along with high efficiency.
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Therapeutic effect of Endep.
Has a relaxing effect on the skeletal musculature
Mechanism: the drug increases the content of a specific amino acid (GABA-gamma-aminobutyric acid) in the central nervous system, thereby reducing the excessive excitability of brain cells. All this leads to a decrease in the flow of nerve impulses to the skeletal muscles, thereby eliminating the risk of seizures.
It protects the nerve cells of the brain and improves metabolic processes in them
Mechanism: blocks calcium channels of nerve cells, this prevents premature destruction and death of nerve cells under the action of their own enzymes.
Valproic acid normalizes metabolic processes and improves the connections between neurons. It increases the life expectancy of neurons, stimulating growth factors and increasing the content of special protective protein in the nerve cells (neuroprotective bcl-2 protein).
Stimulates the growth of nerve cells and promotes the formation of a well-developed neural network of the brain. This mechanism helps with the successful use of an Endep for the treatment of encephalopathic epilepsy in children and is the first choice drug in the treatment of such diseases. With encephalopathic epilepsy, there is immaturity of the nervous structures of the brain, which forms pathological discharges in them, provoking epileptic seizures.
Has anti-tumor effect.
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Mechanism: Valproic acid suppresses the activity of a special enzyme (histone diacetylase), which disrupts the normal maturation of cells and triggers the process of their uncontrolled multiplication.
Absorption and excretion from the body
When ingested, the ender is well absorbed. The greatest concentration of the drug in the blood is determined after 2 hours. After 8 hours, the concentration is reduced by half. The drug is excreted in the urine.
Indications for use.
All kinds of epileptic seizures:
Common seizures (generalized)
Such attacks are characterized by: sudden loss of consciousness, and seizures in all groups of skeletal muscles. In this case, the changed electrical activity captures the entire surface of the brain. There are the following types of common seizures: tonic, tonic-clonic, myoclonic, atonic, absentia.
Tonic – loss of consciousness is accompanied by excessive increase of tone in skeletal muscles
Tonic-clonic – loss of consciousness is combined with tonic convulsions, which are joined by rhythmic muscle twitching in all parts of the body (clonic convulsions).
Transient loss of consciousness from 1 to 25 seconds, while the muscle tone does not change. Usually a person with absans performing normal actions, suddenly freezes, and then again continues the action.
Myoclonic – fast twitching of the muscles, more often of the hands, while the consciousness is not lost.
Atonic – a sharp drop in muscle tone, accompanied by loss of consciousness.
Localized seizures (partial).
Characterized by the emergence of a focus of altered electrical activity of the brain in a strictly restricted zone. In some parts of the body there are muscle twitchings or unpleasant sensations in the head, abdomen, leg, arm, etc. Consciousness remains preserved.
West and Lennox-Gastaut syndromes;
West syndrome – children usually suffer up to one year, manifested by frequent epileptic seizures, a violation of the rhythm of the heart, as well as a lag in mental and physical development.
Lennox-Gastaut syndrome – occurs in children from 2 to 8 years. In the syndrome, there are various generalized epileptic seizures (absans, clonic, atonic seizures), accompanied by mental retardation.
Bipolar affective disorder or manic-depressive psychosis (treatment and prevention). Bipolar affective disorder is a mental illness in which the depressive and manic state alternates, or their simultaneous manifestation.
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Contraindications of Endep.
Severe liver damage, acute or chronic hepatitis;
Porphyria; leukopenia; thrombocytopenia, hemorrhagic diathesis;
Application simultaneously with mefloquine, lamotrigine, preparations of St. John’s wort
Severe pancreatic disease.