People suffering from venous thrombosis or varicose veins are often prescribed funds designed to reduce blood clotting and thereby resist thrombosis. Among the variety of medicines of this group, its effectiveness is the drug Coumadin. Instructions for use will tell you about its pharmacological action and the recommended doses of such medication.
Structure of the preparation
The drug is produced in the form of flat-cylindrical tablets, in each of which there is 2.5 mg of active substance – sodium warfarin. Among the auxiliary components present in the drug, it is worth highlighting: lactose monohydrate, povidone K25, magnesium stearate and potato starch.
The drug Coumadin is an anticoagulant. In a clear language, this drug reduces blood coagulability. This is due to the ability of the drug to reduce the activity of vitamin K, which has a direct effect on blood coagulability.
From the above, it can be understood that Coumadin is an indirect action coagulant, because it does not directly affect the coagulability of the blood. That is why the effect of the use of the drug develops slowly. It should be noted that indirect coagulants are prescribed in cases where a prolonged reduction in coagulability is necessary, as well as to prevent the appearance of repeated thrombi. The effect of using Coumadin appears on the 4th day of regular medication, and it disappears after a similar period of time after taking the last pill.
Indications for use
The drug Coumadin is prescribed in the following pathological conditions:
Treatment and prevention of clots and blockages in the vessels;
Blockage of the pulmonary artery;
Severe forms of thrombosis;
Formation of blockages in the veins after surgery;
Relapse of myocardial infarction;
Prosthetics of blood vessels or heart valves;
Recurrent thrombus formation in the pulmonary artery;
The appearance of thrombi in the arteries of the brain.
The preparation is produced in tablets of 5, 3 and 2.5 mg. The optimal dosage should be selected by a specialist, taking into account the patient’s condition and the existing disease.
Take Coumadin tablets once or twice a day, washing them with water. More precise dosage and duration of the medication will be indicated by the attending physician. In most cases, the dosage is from 2 to 10 mg. The course is long and usually is 6-12 months. In the case of a surgical procedure, which increases the risk of thromboembolic complications, the medication is started 3 days before the operation.
In some conditions, the use of Coumadin is unacceptable. Such ailments include:
Recently transferred ophthalmologic and craniocerebral operations;
The conditions under which pathological changes in blood are observed;
Aneurysms (protrusion of the vein or artery wall);
Pericarditis (inflammation of the heart membrane);
Pathology of the genitourinary system, respiratory tract, as well as ulcerative lesions of the digestive tract;
Severe kidney and liver damage;
Severe arterial hypertension;
Pregnancy and breast-feeding.
Knowing the contraindications for Coumadin, the instructions for use mention some side effects. So, when taking this medication, fatigue, headache, taste disturbance and dizziness may occur. In addition, there may be diarrhea, epigastric pain, jaundice, nausea and vomiting, hepatitis or cholestasis. In rare cases, taking Coumadin can provoke dermatitis, hives and itching.