Medication Cordarone is a well-known cardiovascular agent, which is widely used to eliminate angina and arrhythmia. Those who are interested in the composition, indications for use and analogues of the drug Cordarone, the instruction of use will give a detailed report in this publication.
Structure of the preparation
In pharmacies, you can find this medication in round dividable tablets, each of which has 200 mg of active substance – amiodarone hydrochloride. In addition, the product is released in a pale yellow solution, the ampoule of which contains 150 mg of the active ingredient. In Cordarone is also present: polysorbate, water and benzyl alcohol.
Getting into the human body, the active substance of the drug Cordarone has an anti-arrhythmic effect, which manifests itself in the blockade of adrenoreceptors, in the increase in the refractory period (the time of disappearance of the excitability of the nervous tissue), and in decreasing the excitability of the myocardium. In addition, the drug Cordarone fights with angina by increasing coronary blood flow and reducing myocardial oxygen consumption. This remedy is quick-acting, as it manifests its activity in the body after 15 minutes, acting for at least four hours.
Indications for use
Medication Cordarone are prescribed by medics to get rid of an attack of paroxysmal tachycardia, as well as tachycardia paroxysmal non-ventricular or ventricular (in the case of ventricular contractions of high frequency). In addition, this drug can be used to prevent atrial flutter, atrial fibrillation, as well as non-ventricular paroxysmal tachycardias.
In tablets, this medicine is usually taken at 700-800 mg per day, divided into 3-4 doses. Approximately two weeks later, when the amount of Cordarone taken was brought to 10 g, specialists prescribe a maintenance dose of 3 mg / kg of weight, though not more than 400 mg / day.
In tablets, this remedy is not prescribed to persons with intolerance to iodine and amiodarone, people with thyroid dysfunction, hypokalemia, pulmonary disease and heart failure. In addition, this medicine is not allowed to be used by nursing mothers, pregnant women and children under the age of eighteen.
Cordarone solution is not prescribed in the case of a sinoatrial heart block, with a sinus node weakness, sinus bradycardia, and all the above conditions.
Considering the side effects of the medication Cordarone, the instructions for use highlight the following possible conditions: hyperthyroidism, hypotension, bradycardia, hypothyroidism, lipofuscin corneal epithelial deposition, and photosensitization. Moreover, the patient may experience a severity in epigastric or liver dysfunction, nausea, pneumonitis and alveolitis.