Medical preparation Colchicine is the oldest antirheumatic medicine created back in the time of the existence of Colchis. The first mention of the drug in historical chronicles dates back to the 6th century BC. It is described in the treatise of the scientist medics Alexander Tralsky, where the doctor compares the medicine with the fingers of the ancient Greek god Hermes, calling it Hermesodactyl.
Indications for treatment with Colchicine
The drug Colchicine is recommended to buy for the treatment of patients with gouty arthritis. Moreover, the most effective medicine for acute attacks, when an acute gouty attack is being conducted. The medicine also helps with the initial manifestations of gout, it is also used to maintain remission.
In addition to gout, the preparation Colchicine for treatment is equally effective:
Familial Mediterranean fever (periodic disease);
Individual forms of phlebitis;
Inflammatory diseases in dentistry and ENT-practice.
Gout is a disease of heterogeneous etiology that grows into a chronic form in most cases. This is due to its late detection because of the often washed out symptoms at first. The pathogenesis of the disease is expressed in the violation of the exchange of uric acid and increasing its concentration in the blood. Gout is always accompanied by hyperuricemia, but the presence of hyperuricemia does not mean that a person is ill with gout. However, the presence of gout means that hyperuricemia is present. Excess uric acid leads to the accumulation of its crystals on the walls of the joints and inside them. Urates, forming colonies, gradually accumulate in tophi, which lead to rapid disability of the patient without providing timely treatment.
Behcet’s disease is a systemic vasculitic disease that affects most men (3: 1). The disease is severe, many organs can be affected simultaneously or one of them. The eyes, skin, large joints and mucous membrane of genital organs are most often attacked.
Periodic illness, or familial Mediterranean fever, is a rare genetic disease, manifested in recurrent fever attacks, severe pain in the joints and abdomen.
Contraindications, interactions and side effects
Contraindications to the use of the drug Colchicine
The drug is contraindicated for individual incompatibility, it can’t be used by pregnant women and people who have reached the senile age. Drug is contraindicated for neutropenia, alcoholism, severe violations in the hepatic and / or kidneys, with serious damage to the bone marrow, purulent infections, serious cardiovascular diseases and alcoholism.
Side effects in the treatment of Colchicine
Side effects occur most often from taking high doses of the drug. In particular, there may be vomiting, tidal nausea, cases of anorexia, diarrhea and other disorders. There may be myelosuppression, but mostly with prolonged treatment, signs of reversible alopecia, hepatic and / or renal failure are possible.
There were signs of a depressive state, myopathy, peripheral neuritis, fast asphyxia during withdrawal, malabsorption syndrome (B12 deficiency).
Allergic manifestations, anaphylactic reactions are possible in case of an overdose.
From the side of the central nervous system, isolated cases (with increased doses and prolonged use) of confusion of consciousness, violation of coordination of movements and orientation in space were noted. All these phenomena were reversible with the abolition or reduction of the therapeutic dose of the drug.
Interaction of Colchicine with other drugs
First of all it is necessary to pay attention to the fact that the preparation negatively affects the absorption of cyanocobalamin (vitamin B12) and vice versa. It is an amplifier for any depressive and sympathomimetic drugs.
Complex application with non-steroidal anti-inflammatory drugs and similar medications that stimulate the challenge of myelodepression may increase the risk of developing thrombocytopenia and leukopenia at times.
The use of cytostatic agents during chemotherapy reduces the anti-gouty activity of the drug, because in this case the concentration of urate in the blood increases.