The drug belongs to the pharmacotherapeutic group of antidepressants. His appointment as a doctor of the appropriate profile is made in the following cases:
In the treatment of depressive conditions, regardless of the causes that caused them;
To prevent the recurrence of such conditions;
Treatment of panic disorders;
Obsessive – compulsive disorder.
For adults, the drug is prescribed daily, once a day, at a convenient time for regular use, regardless of eating. The antidepressant effect is stable in the period from two weeks from the moment of treatment to one month. During this time, the attending physician should optimize the dose of the drug, which allows to maintain the patient’s condition at the proper level.
Treatment of depression with the help of Celexa is symptomatic, therefore it is produced over a long period of time. Therapy usually lasts about six months after recovery in order to avoid relapses. In a number of clinical cases, taking the drug may continue for several years. Patients of the elderly and senile age are given an initial dose of half the standard dose for an adult. The maximum recommended daily dose in this case is ten to twenty milligrams.
Side effects of the drug are usually short-term and minor. They are observed during the first two weeks of treatment and pass gradually with the recovery of the patient. Digestive disorders: hypo-salivation (12%) nausea / vomiting (8%) constipation (7%) and sometimes – diarrhea loss of appetite hypersalivation dyspepsia. These adverse reactions can also be signs of an existing disease. Sleep disturbance: decreased sleep duration (8%) sedation (7%). Other adverse reactions: tremor increased sweating (11%) headache (9%) dizziness (6%) sometimes – palpitations cold sensation circulatory disorders impaired urination disorder accommodation mydrias confusion. These adverse reactions were less frequent and were easier than with tricyclic antidepressants. It should be noted that patients with affective disorders often develop symptoms from the autonomic nervous system (for example, dry mouth) that leads to depression. Compared with tricyclic antidepressants in the application of Celexa, an increase in body weight and anticholinergic side effects were not observed. Celexa does not have a cardiotoxic effect, but it can strengthen the already existing sinus bradycardia.
Hypersensitivity to citalopram or any other component of the drug. The drug is not prescribed to patients taking MAO inhibitors (MAO) and within two weeks after discontinuation of their use. Treatment of MAO inhibitors should begin no earlier than 7 days after discontinuation of the drug.
Features of the application.
Celexa should not be used together with MAO inhibitors. Treatment with Celexa can be started 14 days after discontinuation of treatment with non-selective MAO inhibitors, or though one day after stopping the use of moclobemide or selegiline. Treatment with MAO inhibitors can begin 7 days after stopping Celexa. In some patients with panic disorders, symptoms of anxiety may occur at the onset of Celexa treatment. This paradoxical exacerbation of anxiety symptoms is clearly within the first few days of treatment and passes during the first two weeks. Therefore, it is recommended to begin therapy with Celexa with small doses to alleviate these paradoxical reactions. As with other antidepressant medications, the likelihood of suicide in patients with depression can be stored until a significant remission is achieved. Patients with a risk of suicide should not have access to drugs in large quantities. If the patient’s condition passes into a manic phase, Celexa treatment should be discontinued. Caution should be given to Celexa in patients with epileptic seizures in the anamnesis. Selective inhibitors of reverse neuronal seizure of serotonin can alter the blood sugar levels of diabetics. In these cases, a dose adjustment of Insulin or oral anti-diabetics is necessary.